3 failed ivf, next step??

Try again! - This is the only good answer and a good IVF doctor’s answer will be exactly this. Of course, he may make changes, based on your response, and he will explain these to you. A good doctor will not order a bunch of expensive tests after each IVF failure and doctor will make sure that his patients have realistic expectation about the entire IVF process. If you want to be a mature IVF patient, educate yourself about the process. This will help you to have sensible expectations of IVF treatment. It will protect you from an emotional breakdown; and from unnecessary tests and treatments.
Here's some statistics on the frequency of conception and successful pregnancy: Probability of success using donor egg – 65% (it slightly change with recipient age). If you are from 29 to 59 your probability of successful conception, bear and give a birth is 55-65%. Using your own egg reduces the this probability on 5% every year. By the age of 42 your chances to get pregnant and bear your child with your own egg is about 7%. I don't think we can pinpoint very well specific factors or nutrients that might affect egg quality. However, folate is a good candidate. It helps with cell growth.
Also I've recently read an article about a completely unique method for infertility treatment. It's called the mitochondria replacement therapy. Here are some of the points:
#1 It offers patients who are above 40 and for those, who suffer from low levels of AMH, an innovative program that makes it possible to get pregnant with their own eggs. This program gives women, who underwent numerous unsuccessful IVF cycles, aged 40+, patients with low mitochondrial functional activity, an excellent chance to give birth to a child who shares a genetic relationship with her and her partner.
#2 To carry out such a procedure, an egg donor with a high functional activity of mitochondria, a patient, and sperm for in vitro fertilization are required. Healthy functionally active mitochondria are taken from a donor’s oocyte and integrated with the patient’s cells. Next, fertilization with sperm and transfer of a healthy embryo into the patient’s uterus is performed. Mitochondria donation is a unique assistive reproductive technology, which is basically the implantation of a healthy and functionally active donor mitochondria into the cells of an infertile patient, that provides the patient’s cell with the necessary energy and contributes to successful pregnancy.
#3 Mitochondrial DNA and Human DNA are different things. It only gives that necessary energy to the oocyst and helps with developing an embryo and make it stronger. DNA is in the core of the mitochondria, which are not used for donation. Therefore, genetically, mitochondria have no effect on the embryo!
Hope this helps.

Surrogacy might be the best option here. Although as I am no specialist, I can't advise you anything.
Book an appt and see what your gp has to offer.

I for my part will just recommend the agency I have signed with that helped us a lot. It is World Center of baby. it is located in Ukraine. And it is great. they have matched our Sm in a month and a half and she is already pregnant. this is a miracle for us.

If it happens you'll be looking onto surrogacy, I just thought this information might be useful for you~
The cost of every program at bio tex com is divided into 6 payments. Every payment is made on the certain stage of a program. The detailed payments schedule can be found in every contract. Standard surrogacy package (Waiting time: up to 4 months) 39.900 euros provides:
Medical tests and checks for all participants of the program (Intended parents, surrogate mother and egg donor). Medications for all participants of the program (Intended Parents, SM and Egg Donor). Unlimited IVF cycles. Pregnancy care (pregnancy monitoring) for the SM. DNA paternity test in thier partnering laboratory. PGD service to detect the possible genetic abnormalities (the sex of a baby(s) is not detected). The child’s doctor attends the baby every other day. In case of miscarriage compensation to a surrogate mother is paid by them. In case of the premature birth all the expenses related to additional medical treatment, special medical equipment utilization etc. are covered by them from the day of birth.
Then legal support and paperwork: Surrogacy contract elaborations. Support on the final stage of the process for obtaining of the birth certificate for a baby(s) and travel documents for them to leave the country.
Organization and Coordination: Customers are provided with the babysitter services for 4 hours a day in a daytime. Customers are provided with the support package: transportation, food, a room in the hotel
of higher class, smartphone and SIM card of Ukrainian mobile operator. Accommodation is provided for two (2) months after birth. Thus the program doesn’t cover: twin pregnancy compensation (EUR 3000).

You know, guys, what bothered us the most with the previous clinic was that our RE used to never make any recommendations for us after each failure..We did a lot of testing..And evantually found out I had lost immunity to Rubella. So I got re-vaccinated and since it's a live vaccine had to wait 1 month before trying again. He did recommend a supplement for dh. Which I suspect accounts for some of the difference between cycles..Dh was taking them on a regular basis. But seems this didn't help us much. I wonder what else could we both do to boost chances and not see dreadful bfn..I am shocked at the grief I felt. I was so hopeful, and that first bfn after IVF#1 was so emotional. Even more than any of the other months of trying and bfn.
I'm also just not sure if continuing with IVF makes sense or if there are other options to boost our chances before we go to egg donation..Which I'm not sure if we can really accept.. I've also read a thing about mitochondria donation Bio tex provides..This is surely another point for our further research..May god help us to stay strong.

marhiya wrote:
hey there! I hope you are doing great. IVF is a great process. a lot of people go for it. it helps couples that are unable to have a baby of their own. and people having a hard time conceiving. it is a little painful but worth it. hope it goes well for you.

In general, the process of IVF involves the following steps. First, a woman takes hormones to cause "superovulation'' .which triggers her body to produce many eggs at one time. Once mature, the eggs are collected from the woman, using a probe inserted into the vagina and guided by ultrasound. The collected eggs are placed in a dish for fertilization with a man's sperm. The fertilized cells are then placed in an incubator, a machine that keeps them warm and allows them to develop into embryos. After 3 to 5 days, the embryos are transferred to the woman's uterus. It takes about 2 weeks to know if the process is successful. Even though the use of hormones in IVF is successful in treating infertility related to endometriosis, other forms of hormone therapy are not as successful. In addition, the hormones used during IVF do not cure the endometriosis lesions. It means that pain may recur after pregnancy and that not all women with endometriosis are able to become pregnant with IVF. Researchers are still looking for hormone treatments for infertility due to endometriosis. There are so many things we still don't know. and the world of infertility treatments is so complicated. But, fortunately, we've got some of these beautiful options nowadays like IUI, IVF (OE&DE), ICSI, surrogacy, mitochondria donation etc. We're lucky, surely. smile

My advice to you would be that don't give up. IVF does not guarantee success. It's supposed to assist in the conceiving procedure. You can always mix up and try different things. I would suggest consulting an expert. Visit a fertility clinic, explain the situation, discuss with the medical history. It should get better! Good luck to you!

Hi all, am just chimming in here again. Have recently read another pieceof info on mitochondrial donation. Thought this might be useful, so am sharing~
Mitochondrial donation: an opportunity for middle-aged couples to become parents of a healthy child
Some childless couples, especially those over the age of 40+, who are trying to become parents through in-vitro fertilization (IVF) meet with failure. Why the emphasis is put precisely on the age of forty years? Because medical statistics confirms that at the age of 40 or 45, it is much more difficult for a woman to not only get pregnant, but also to bear a healthy child.
With age, women are less likely to get pregnant
This fact does not mean that it is absolutely dangerous for a woman at the age of 40+ to become pregnant and give birth: hundreds of aged happy mothers confirm this. However, with age, a woman’s ovarian reserve decreases (the so-called stock of healthy eggs-oocytes), which reduces the chances of getting pregnant. In addition to this problem, in some aged patients who could not become pregnant using IVF, there is a low mitochondrial activity. These organelles are the most important components of any cells. Egg cells, female reproductive cells, also cannot do without functioning mitochondria, which, in their turn, not only provide oocytes with energy, but also have their own hereditary DNA material. With a deficiency of active, functioning mitochondria in the female eggs, often even a healthy embryo placed in the woman’s uterus does not take and the pregnancy does not occur. In this case, successful IVF is possible with using donor mitochondria.
What is the basis of mitochondrial donation
Mitochondrial donation is also called the “three parents method”: the procedure is based on the transplantation of mitochondria from a female donor into an egg cell of a patient who wants to become pregnant, which is then fertilized in vitro with the sperm of a husband or partner.
That is why, when there is a deficiency in functionally active mitochondria in the female eggs, the patient is recommended to have a mitochondrial donation, a procedure that is used in the infertility treatment at the *** reproductive clinic. Healthy donor mitochondria are integrated with the patient’s cells, fertilized, after which a healthy embryo is placed in the woman’s uterus.
Alternative to surrogacy and the guarantee of a healthy baby
This reproductive technology is also an IVF method, enabling families to have genetically healthy children, since the mitochondrial donation uses the egg of a female donor, which does not contain defective mitochondria. The method is also recommended for women with a high probability of the development of mutations in mitochondrial DNA and subsequent severe illnesses in an unborn baby. Thus, mitochondrial donation helps barren women not only to become mothers, but also to exclude a number of genetic diseases. With the help of mitochondrial donation, a woman can bear and give birth to a child on her own without resorting to surrogacy!

Hey, honey. How are you? I hope you're alright. I'm so sorry to hear about your losses. It must have been awful. That is a tough one to take. Don't worry, though. If it's meant to be, it'll happen. Don't give up, so easily. There are lots of other options, too! My prayers are with you. Good luck to you. Sending lots of baby dust, your way. Keep us posted on how it goes. Do get it checked, as well. It's crucial to get a professional opinion on it!

Every couple has right to choose..I'm not against adoption. But I'm among those who tried everything allowing to experience pregnancy myself. I'm ripe age. Faced multiple miscarriages and one ectopic which led me to further complications. Adding POF and low amh we did try 2 ivf cycles to conceive. But they failed. We applied for donor egg with biotex. I hoped we could still use my own egg, but was told it was not going to work. So we used donor egg..Our baby is genetically related to my husband and I'm happy about that. See, this is what we accept. I would love to have my genetically related kids, but I can't. I feel like I don't have right to force my dh abandon this as well. I'm sorry if you're struggling hard to get there. These are the things thousands face..?

The concerns are understandable. The low cost of surrogate pregnancy in Eastern Europe is the most compelling reason I should say. Would-be parents from nearby West European countries including the UK and from as far as Australia and the USA are seeking surrogacy there more and more. The process is well regulated there. Surrogates are usually required to submit photos upon application. Then they undergo testing both physically and psychologically to make sure they are fit. Only women who have given birth before are qualified to become surrogate mothers. Agencies/clinics usually do not accept surrogates who drink, smoke, or take drugs. Typical surrogate moms from Eastern Europe are between 20 and 40 yrs. Prospective parents are given several profiles they can choose from before agreeing to a surrogate mom. As I’ve mentioned above, before going straight for pregnancy, a surrogate would have to undergo extensive medical testing. What tests a woman has to go through depends on the country’s law. Usually these involve gynecological examinations, blood tests, and screening for various sexually-transmitted diseases among many others. She also has to go through psychological screening. She would usually be given continual counseling by the agency along with the parents. In countries where commercial surrogacy is legal like Ukraine, the surrogate will have zero parental rights over the child!!! Gestational surrogacy cases may require some paperwork so that you can be legally named parents of the child. Otherwise, all you need to worry about is acquiring an exit visa for the child!!
But as usual there are some cons. While more affordable and financially feasible for you, you will unfortunately not be able to personally screen potential mothers for the surrogate pregnancy process in Eastern Europe. Since your baby’s life depends on the surrogate for nine months, it’s best to check your agency’s/clinic’s reputation when it comes to choosing and screening surrogate moms. Make sure your agency/clinic performs regular checks and home visits on the surrogate since you can’t be there physically to do it on your own. One thing to add. All new parents must apply for citizenship and travel visas to return home with their newborn babies. This is quite easy in countries like the United States or the UK. However some countries have steadfastly refused to issue citizenship to surrogacy babies, including France and Germany. All couples who are considering surrogacy in Ukraine should check with a local family law expert to see what will be the process for establishing citizenship and bringing the baby home. Hope this is useful.

RebecaM wrote:
Hey, honey. How are you? I hope you're alright. I'm so sorry to hear about your losses. It must have been awful. That is a tough one to take. Don't worry, though. If it's meant to be, it'll happen. Don't give up, so easily. There are lots of other options, too! My prayers are with you. Good luck to you. Sending lots of baby dust, your way. Keep us posted on how it goes. Do get it checked, as well. It's crucial to get a professional opinion on it!

I’d say this depends purely on a clinic. Ladies are saying ivf would not work at 45 yrs. Well, some clinics do have this sort age restrictions. But a highly qualified one will make benefits from age matters, you know, saying, ‘look, guy, we treat the toughest cases!’ Of course ivf is still possible but success rates are much lower comparing to those of surrogacy treatment. Anyway, I’d not waste time on natural ttc 45+ and go straight to medical help. This is my point…